Nattobiotic 90caps (Arthur Andrew Medical)

Nattobiotic is the world's first raw nattokinase dietary supplement, as well as the first and only raw nattokinase synbiotic.

Nattobiotic contains raw natto, including its naturally occurring antioxidants, vitamin K2, 10 essential amino acids and nattokinase-producing probiotic Bacillus subtilis plus an added prebiotic, Isomalto-Oligosacharide.

Nattobiotic is specifically formulated to address fibrin imbalances in the body. Fibrin is a protein that plays a major role in blood clotting and scar formation, making it an essential component of the healing process and vital for maintaining our health and general well being. However, fibrin overproduction and impaired fibrin clearance has been implicated in many of today's most devastating and deadly diseases, including cardiovascular disease, interstitial lung diseases, Alzheimer's disease, cystic fibrosis, fibromyalgia, multiple sclerosis, scleroderma and endometriosis.

Benefits of Raw Nattokinase

Nattokinase is a fibrinolytic (fibrin-dissolving) enzyme derived from a Japanese fermented soybean food called natto [1-4]. These soybeans are fermented with the Bacillus subtilis bacteria [3,4] which produces an enzyme called nattokinase. The resulting food, natto, has a very slimy texture, sour taste and strong smell that is very unappealing to some. Despite its questionable taste, natto has been shown in numerous studies to have a number of health benefits. For its use in nutritional supplements, the nattokinase enzyme is typically extracted and purified in a laboratory setting.

Natto has been involved in numerous studies, and the results show that it has the most potent oral fibrinolytic activity of over 200 foods tested [6]. Nattobiotic's unique formula boosts the powerful fibrinolytic activity of nattokinase by utilizing the benefits of raw natto food rather than a nattokinase enzyme extract. Raw natto inherently contains vitamins, minerals, antioxidants and probiotics that are generally removed during the nattokinase extraction process. These important co-factors make the fibrinolytic enzymes more bioavailable in the body, increasing their effectiveness and impact. 

Nattobiotic not only contains nattokinase but also the live probiotics, antioxidants, nutrients and other enzymes created during the fermentation process. This gives Nattobiotic's exclusive synbiotic formula the highest Fibrinolytic Unit (FU) activity among the major brands of nattokinase supplements, allowing it to hydrolyze 5,000 units of fibrin per dose (2 capsules), and optimizes its health benefits. 

Nattokinase & Fibrinolysis

Fibrin is naturally produced in the body by a protein called thrombin and is degraded by a protein called plasmin. Usually these processes exist in a delicate balance; however, in many diseases and conditions, fibrinolysis is impaired and fibrin begins to accumulate in the body. Nattokinase supplementation, however, can tip the balance back in favor of fibrin removal using two different mechanisms. 

Firstly, nattokinase is a naturally fibrinolytic enzyme, which means that it can literally dissolve fibrin whether it is holding together blood clots or is part of scar tissue [2]. In fact, nattokinase is actually 4-times more potent than the body's own plasmin [7].

Nattokinase also blocks the activity of plasminogen activator inhibitor 1 (PAI-1), which boosts its fibrinolytic capabilities even more [8,9]. High levels of PAI-1 are directly linked to impaired fibrin degradation and removal because PAI-1 blocks the body's natural production of plasmin [10]. By blocking PAI-1, nattokinase promotes the conversion of more plasminogen into plasmin, increasing the amount of fibrinolytic proteins in the blood.

Vitamin K2 

According to the Rotterdam researchers, the reduction in cardiac deaths associated with higher vitamin K2 intake is probably the result of decreased arterial calcification [21]. Arterial calcification is a significant risk factor for atherosclerosis, heart attack and stroke. However, vitamin K2 has been shown to not only prevent coronary calcification [23], but also help remove it. A 2007 study discovered that higher vitamin K2 intakes reduced arterial calcification already present in rats by approximately 50% [24].

Vitamin K2 may also exert cardio-protective effects by stopping dangerous blood clots from forming near the inner surface of blood vessel walls [21]. Vitamin K is essential for the functioning of several proteins involved in blood clotting  [25], which is why it is the target for anticoagulant drugs like warfarin. However, according to Dutch Professor Cees Vermeer, vitamin K2 helps inhibit clot formation when blood vessels are intact and promote clotting when blood vessels are broken, thereby regulating the body's natural clotting factor mechanisms. As a result, inhibiting vitamin K2 may actually be detrimental to vascular health. 

Synbiotic Benefits

Each Nattobiotic capsule contains 1 billion colony-forming units (CFUs) of probiotic B. subtilis, as well as a prebiotic fiber, Isomalto-Oligosacharide. This mixture of pro- and prebiotics is known as a synbiotic [31].

Bacillus Subtilis

Probiotics are "good" bacteria that boost health when taken orally and are allowed to grow and multiply in the body [32]. B. subtilis is especially suited for growing in and colonizing the gastrointestinal tract because it is a spore-forming bacteria. Most bacteria are destroyed by the acidic pH range, mainly thriving in the more alkaline lower GI tract, but spores are able to withstand a broader range of pH and temperature [33,34]. This improves the chances that the probiotic strain will be able to thrive in the GI tract.

Research has shown that natto intake can increase the number of B. subtilis in the gut, as well as affect the metabolic activity of the intestinal microflora [35,36]. This is because once they are established in the small intestine, B. subtilis probiotics act like tiny factories, producing beneficial vitamins (like vitamin K2), minerals, antioxidants and enzymes (like nattokinase) that help support and maintain digestive and overall good health [37].

In one clinical study, 80 elderly volunteers were given B. subtilis supplements for 12 weeks. At the end of the study period, the researchers observed reductions in the participants' total cholesterol levels [31]. It is possible that this may be linked the production of nattokinase by these bacteria once they colonized the digestive tract. 

What is Nattöbiotic?

Nattöbiotic is the world's first and only RAW Nattokinase Probiotic. Nattöbiotic contains raw natto, including its naturally occurtin antioxidants, vitamin K2, 10 essential amino acids and nattokinase producing probiotic Bacillus Subtillis Natto and and added prebiotic, Isomalto-Oligosacharide.

How Does Nattöbiotic Work?

Taken on an empty stomach, Nattokinase, a fibrinolytic (fibrin digesting) enzyme, enters the bloodstream via the small intestine. Nattokinase breaks down fibrin within the body; its inherent ability to digest dead tissue enables the enzyme to cleanse the cardiovascular system and improve circulation.

Why Should I Take Nattöbiotic?

Anyone that would like to support normal circulatory health naturally should take Nattöbiotic. The Japanese have benefited from the ancient food Natto for centuries. All the benefits of Natto can be experienced in supplement for with Nattöbiotic.

Can I Take Too Much Nattokinase?

Nattöbiotic can safely be incorporated into your supplement regimen. There have been no indications that one can over-dose from the use of systemic enzymes such as Nattokinase. However, it is important to follow dosing instructions unless otherwise directed by your healthcare provider.

Is Nattöbiotic Enteric Coated?

Nattöbiotic is left in its raw form so it is not enteric coated. It has been proven that lymph receptors even in the stomach will absorb Nattokinase, so enteric coating would prevent this. Not to mention, the traditional Japanes food “Natto” is not enteric coated, so Nattöbiotic isn’t either.

Nattöbiotic

Dehydrated Raw Natto Food in supplement form. Nattobiotic provides all the same benefits of eating the traditional Japanese food Natto. It contains raw nattokinase, vitamin K2, antioxidants, B.subtilis natto, 10 essential amino acids and prebiotics.

Nattokinase

A fibrinolytic enzyme that can help to maintain normal blood viscosity and normal cardiovascular health. Nattokinase can support healthy fibrin concentrations. It has antioxidant effects that may be beneficial to promote normal prostate health, and aids in the elimination of free radicals.

B. subtilis Natto

Bacillus Subtilis Natto, a spore form probiotic that inherently produces more nattokinase enzymes which are absorbed into the bloodstream.

(IMO) Isomalto-Oligosaccharide (prebiotic)

IMO is a natural, certified organic prebiotic fiber, providing low calorie and soluble prebiotic fiber for human digestive health. IMO is non-GMO, sugar-free and gluten-free. When IMO enters the large intestine, it is fermented by the indigenous bacteria, providing fertilization of beneficial microflora. It has been clinically shown to greatly increase the number of indigenous bacteria in the digestive tract. In addition to being Kosher and Halal, our IMO products are FDA GRAS and approved by Health Canada. Clinical studies have shown IMO to cause the least flatulence in comparison to inulin and FOS.